GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs1577917 | 1 | rs10498958 | chr6:86649705 | SNHG5 | chr6:86386726-86388451:- | 0.54 | 9.49 | 2.44E-19 | Response to antipsychotic treatment |
| BLCA | cis | rs80285556 | 1 | rs10500303 | chr19:50512033 | SIGLEC16 | chr19:50472912-50479075:+ | 0.59 | 5.55 | 5.41E-8 | antipsychotic drug dosage in schizophrenia or schizoaffective disorder |
| BLCA | cis | rs10508921 | 1 | rs10508921 | chr10:52010708 | FAM21A | chr10:51827684-51893268:+ | -0.36 | -4.38 | 1.55E-5 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| BLCA | cis | rs17065323 | 1 | rs10514847 | chr13:44626749 | KIAA1704 | chr13:45563687-45607742:+ | -0.66 | -4.97 | 1.03E-6 | Uric acid levels |
| BLCA | cis | rs17065323 | 1 | rs10514847 | chr13:44626749 | NUFIP1 | chr13:45513384-45563613:- | -0.67 | -4.52 | 8.14E-6 | Uric acid levels |
| BLCA | cis | rs9815354 | 1 | rs1052501 | chr3:41925398 | ULK4 | chr3:41288091-42003660:- | -0.64 | -9.91 | 9.53E-21 | Diastolic blood pressure |
| BLCA | cis | rs6087771 | 1 | rs1062794 | chr20:30381758 | COX4I2 | chr20:30225691-30232800:+ | 0.2 | 4.23 | 2.93E-5 | Subcortical brain region volumes |
| BLCA | cis | rs7112513 | 1 | rs10732856 | chr11:116907113 | PCSK7 | chr11:117075789-117102811:- | -0.39 | -4.89 | 1.51E-6 | Protein quantitative trait loci |
| BLCA | cis | rs4660306 | 1 | rs10736426 | chr1:45984353 | CCDC163P | chr1:45960581-45965646:- | 0.73 | 15.02 | 1.96E-40 | Homocysteine levels |
| BLCA | cis | rs9783347 | 1 | rs10741741 | chr11:18342081 | GTF2H1 | chr11:18343816-18388590:+ | -0.29 | -5.86 | 9.8E-9 | Pancreatic cancer |
| BLCA | cis | rs9783347 | 1 | rs10741742 | chr11:18342160 | GTF2H1 | chr11:18343816-18388590:+ | 0.32 | 6.17 | 1.75E-9 | Pancreatic cancer |
| BLCA | cis | rs703842 | 1 | rs10747783 | chr12:58176614 | FAM119B | chr12:58166383-58176323:+ | 0.28 | 4.37 | 1.62E-5 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs10747783 | chr12:58176614 | TSFM | chr12:58176536-58191367:+ | -0.38 | -6.71 | 7.19E-11 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs10747783 | chr12:58176614 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.23 | -3.99 | 7.9E-5 | Multiple sclerosis |
| BLCA | cis | rs2275426 | 1 | rs10749860 | chr1:46328210 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7 | 1.18E-11 | Body mass index |